Fireworks display will be the mark of the vessel's departure from Britain's major port of Southhampton as for her last trip.
The QE2 which was first launched by Queen Elizabeth II in 1967, will be delivered In November to Dubai World, the investment company that manages a portfolio of businesses and projects for the Dubai government.
The QE2 is the longest-serving ship of the Cunard Line. The 963-feet (294-metre) long ship weighs 70,000 tonnes and can carry up to 1,778 passengers and more than 1,000 crew. Since coming into service it has undertaken 25 world cruises, crossed the Atlantic more than 800 times and carried about 2.5 million passengers.
The ship, which was sold US$100 million in June, will be refurbished and turned into a five-star hotel berthed at a pier at The Palm Jumeirah, the man-made island created using land reclamation by government-owned company Nakheel.
Sultan Ahmed bin Sulayem, Chairman of Dubai World, has called the vessel one of "the wonders of the maritime world".
On Sunday, the liner left Southampton alongside Cunard's latest vessel, the US$592 million, Queen Victoria, which was departing on its maiden world cruise.
The ships will travel together across the Atlantic Ocean to New York City.
The Queen Victoria will replace the QE2 on regular trans-Atlantic crossings.
